Alpha 1-adrenoceptors reduce background K+ current in rabbit ventricular myocytes.
نویسندگان
چکیده
منابع مشابه
Calcium-activated chloride current in rabbit ventricular myocytes.
We have used the whole-cell patch-clamp technique to examine the ionic basis for a transient outward current in rabbit ventricular myocytes. High concentrations of intracellular calcium buffer prevented the current, isoproterenol increased it, and cadmium, nisoldipine, ryanodine, or caffeine blocked it. These data are consistent with a current that is calcium activated, by the calcium transient...
متن کاملRabbit Isolated Ventricular Myocytes
In this study, the hypothesis that mammalian ventricular myocytes possess A2-adenosine receptors was tested. Electrophysiological, contractile, and cAMP responses to the selective A2-adenosine receptor agonists 2-[2-(4-methylphenyl)ethoxyladenosine (WRC-0090) and 2-(2-cyclohexylethoxy)adenosine (WRC-0013) and the nonselective adenosine receptor agonist 5'-(N-ethylcarboxamido)adenosine (NECA) we...
متن کاملRabbit Ventricular Myocytes
Whole-cell calcium current (lCa) and inwardly rectifying potassium current (IK1) were studied in 21-day fetal, 28-day fetal (total gestation, 31 days), 2-5-day neonatal, and adult rabbit ventricular myocytes isolated by enzymatic dissociation. Whole-cell peak lCa and IK, at -100 mV increased significantly after birth. Cell size approximated from cell membrane capacitance also increased with age...
متن کاملRabbit Ventricular Myocytes
on lK.ATP may have certain pathophysiological implications. Increased intracellular proton concentration (pHi) is known to regulate lK.ATP in frog skeletal muscle by increasing open probability. The pHi effect on IK.ATP is not clearly understood in heart because, unlike frog skeletal muscle, low pH; causes IK.ATP run-down in inside-out patches. This would tend to mask any opening effect of low ...
متن کاملRabbit Ventricular Myocytes
The intracellular mechanism underlying the Ca2`induced enhancement of the L-type Ca2` current (Ica) was examined in adult rabbit cardiac ventricular myocytes by using patch-clamp methodology. Internal Ca2` was elevated by flash photolysis of the Ca2` chelator Nitr 5, and intracellular Ca2' levels were simultaneously monitored by Fluo 3 fluorescence. Flash photolysis of Nitr 5 produced a rapid (...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1991
ISSN: 0022-3751
DOI: 10.1113/jphysiol.1991.sp018772